Winnie's Hole is an unusual strategy game with roguelike elements, in which you take on the role of a virus developing inside your host – Pooh. Your goal is to take over more cells, mutate, and gradually increase control over your body until you reach your full potential for biological dominance. The gameplay takes place on a cellular level, where you explore the procedurally generated interiors of the host's body. You place virus blocks of different shapes and properties to spread infection, activate new abilities, and gain powerful passives. Each playthrough unlocks new mutations, perks, and virus strains, making each attempt different and offering new opportunities for growth.