Doug and Griff have been best friends since childhood and have always dreamed of remaking their absolute favorite movie: the "classic" Anaconda. Her midlife crisis drives her to finally turn her dream into reality. They travel deep into the Amazon to begin filming. But the fun quickly turns serious when a real giant anaconda suddenly appears - and turns the chaotic-funny film set into a deadly trap. The film they wanted to die for? Could cost her her life in the end ...