The plot of »Dune: Prophecy« is set in the widely ramified universe of the »Dune« novel series by acclaimed author Frank Herbert. The focus is on two sisters from the Harkonnen family, who fight against a threat that threatens to endanger the future of humanity 10,000 years before Paul Atreides came to power. During this time, they founded the mysterious sisterhood, which would later go down in history under the name Bene Gesserit.