Manaus, Brazil: Lebecq is the captain of a small charter boat. He drinks a lot and prefers to leave the real work to his crew. The charter order from Amanda and her brother Scott comes just in time to finally bring some money back into the coffers. The two are looking for their missing father, the anthropologist Nathan, who has gone missing on an expedition up the Rio Negro. However, no one in the group suspects the deadly dangers they will have to face in the depths of the Regenwald. The entire animal world seems to have conspired against the humans who have invaded their habitat. Swarms of piranha attack the boat, poison dart frogs, anacondas, giant spiders and alligators make life difficult for them. When they fall into the clutches of a native tribe, their fate seems sealed... New product