The galactic emperor, His Shadow, is obsessed with a tyrannical mission: to destroy all planets outside the League of 20,000 Planets. His weapon of destruction is the LEXX, a semi-organic spaceship—and the most powerful weapon of annihilation in both universes. Through a series of coincidences, a group of doomed misfits manage to hijack the LEXX. Together, loser Stanley Tweedle, love slave Zev, the undead assassin Kai, the last of the Well-G, and robot head 7-90 escape His Shadow's clutches in the LEXX, venturing into the eerie Dark Zone...