Deep in the swamps of the Everglades, local police manage to dig up a meth drug lab. Unfortunately, they can't prevent a giant alligator from devouring a large package of drugs. The alligator is now running amok, and nothing and no one seems safe from the all-devouring murder machine. Mayor Jensen, however, does not want to make this public, because numerous tourists are expected on Memorial Day weekend. He instructs Sheriff Williams and his son Dante, who now works for the DEA, to take care of the problem. But the alligator is not only looking for more victims, he also urgently needs more drugs in his feeding frenzy...