Rumor has it that it is cursed: the small tropical island of San Miguel. But there is someone who knows the gruesome truth: Frank Brody witnessed a catastrophic experiment with genetically mutated animals on the island, which turned the tropical idyll into a nightmare come true and Brody into a hopeless drinker. The experiment created a creature between man and animal that follows only one urge: the urge to kill. Ten years later, a plane crashes on the island and Scott Davis leads a search for the survivors - completely unsuspectingly. Brody knows that it is now time for him to return to the island. He must try to stop the nightmare...