A group of four young friends, Zack, Gracie, Beth and Corrine, are looking forward to a wonderful hiking holiday in the Blue Ridge Mountains. But even the outbound flight becomes a pure nightmare. Because a Russian scientist has genetically modified, hyper-aggressive, poisonous spiders in his luggage, which spread quickly in the cargo hold and then in the passenger cabin due to a few strong turbulences. From then on, the flight at an altitude of 11,000 meters becomes a nerve-wracking fight for survival ...